retatrutida<\/b> <\/span>logr\u00f3 una p\u00e9rdida de peso sin precedentes.<\/p>\nLos datos provienen de TRIUMPH-1<\/b>, un estudio aleatorio, doble ciego y controlado con placebo que incluy\u00f3 a 2.339 participantes<\/b> adultos con obesidad o sobrepeso sin diabetes.<\/p>\n
A las 80 semanas, quienes recibieron la dosis m\u00e1s alta (12 miligramos) perdieron en promedio 31,9 kilogramos, el 28,3% de su peso corporal<\/b>. El grupo placebo perdi\u00f3 apenas el 2,2%. <\/p>\nResultados que cambiar\u00edan el techo de la medicina<\/h2>\n
![\"El](\"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-1.jpg\")
<\/p>\n
Esas cifras ubican a la retatrutida (elaborado por Eli Lilly) por encima de los dos inyectables m\u00e1s usados contra la obesidad hoy. Otros f\u00e1rmacos como tirzepatida, y semaglutida ayudan a perder alrededor del 20% del peso en un per\u00edodo similar.<\/p>\n
El f\u00e1rmaco retatrutida se administra como una inyecci\u00f3n subcut\u00e1nea una vez por semana<\/b>, debajo de la piel del abdomen, muslo o brazo. Los resultados del nuevo ensayo m\u00e1s llamativos aparecieron en los pacientes con mayor peso. <\/p>\n
Quienes ten\u00edan un \u00edndice de masa corporal (IMC) igual o superior a 35 y continuaron el tratamiento hasta las 104 semanas<\/b> perdieron en promedio 38,5 kilogramos, o el 30,3% de su peso corporal<\/b>.<\/p>\n
![\"El](\"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-2.jpg\")
<\/p>\n
Para tener una referencia concreta: una cirug\u00eda de bypass g\u00e1strico produce una p\u00e9rdida de entre el 30% y el 35% del peso en dos a\u00f1os. \u201cLos resultados son muy impresionantes, sin duda\u201d, afirm\u00f3 la doctora Ania Jastreboff<\/b>, especialista en obesidad de Yale<\/b> e investigadora principal del ensayo, en declaraciones al diario The New York Times<\/i>.<\/p>\n
La experta advirti\u00f3 que la obesidad es una enfermedad cr\u00f3nica y que lo verdaderamente relevante no es solo la cantidad de kilos perdidos, sino \u201clos efectos en la salud de una persona a lo largo de su vida\u201d.<\/p>\n
M\u00e1s all\u00e1 de la dosis m\u00e1xima, el ensayo tambi\u00e9n arroj\u00f3 datos inesperados: con 4 miligramos y un solo paso de ajuste, los participantes perdieron el 19% de su peso, comparable a la dosis m\u00e1xima de Zepbound (tirzepatida).<\/p>\n
Tres hormonas, un solo disparo<\/h2>\n
![\"Los](\"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-3.jpg\")
<\/p>\n
La retatrutida act\u00faa sobre tres hormonas a la vez: el GLP-1<\/b>, el GIP<\/b> y el glucag\u00f3n<\/b>. Los dos primeros ya son el blanco de semaglutida y tirzepatida, pero el glucag\u00f3n \u2014que regula el metabolismo energ\u00e9tico\u2014 no estaba en la mira de ning\u00fan medicamento aprobado hasta el momento.<\/p>\n
Ese triple mecanismo puede tener, no obstante, un costo: los efectos adversos m\u00e1s frecuentes fueron n\u00e1useas (42,4% en la dosis de 12 mg frente al 14,8% del placebo), diarrea (32%) y constipaci\u00f3n (26,1%). <\/p>\n
El 11,3% de los participantes<\/b> con la dosis m\u00e1s alta abandon\u00f3 el estudio por efectos secundarios, una tasa superior a la de otros f\u00e1rmacos contra la obesidad disponibles en el mercado.<\/p>\n
La doctora Caroline Apovian<\/b>, especialista en obesidad de la Facultad de Medicina de la Universidad de Harvard<\/b>, Estados Unidos, explic\u00f3 a The New York Times<\/i> que los 24 millones de estadounidenses con obesidad grave necesitan perder entre 36 y 45 kilogramos para alcanzar un peso saludable, algo que los f\u00e1rmacos actuales no logran en la mayor\u00eda de los casos.<\/p>\n
![\"La](\"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-4.jpg\")
<\/p>\n
La retatrutida ser\u00eda especialmente \u00fatil para personas con obesidad severa porque producir\u00eda la p\u00e9rdida de peso que los medicamentos actuales no alcanzan.<\/p>\n
El laboratorio que desarrolla el f\u00e1rmaco a\u00fan no solicit\u00f3 la aprobaci\u00f3n regulatoria para la retatrutida y los resultados de TRIUMPH-1 todav\u00eda no pasaron por revisi\u00f3n de pares ni se publicaron en una revista m\u00e9dica.<\/p>\n
La compa\u00f1\u00eda prev\u00e9 presentar datos adicionales en las Sesiones Cient\u00edficas de la Asociaci\u00f3n Estadounidense de Diabetes (ADA)<\/b>, y dar\u00e1 a conocer resultados de TRIUMPH-2<\/b> \u2014en pacientes con diabetes tipo 2\u2014 y TRIUMPH-3<\/b>, en personas con enfermedad cardiovascular establecida.<\/p>\n","protected":false},"excerpt":{"rendered":"
M\u00e1s de 1.000 millones de personas en el mundo viven con obesidad y la cifra no para de crecer: la prevalencia entre adultos se duplic\u00f3 entre 1990 y 2022, seg\u00fan la Organizaci\u00f3n Mundial de la Salud (OMS). En ese contexto, los resultados de un nuevo f\u00e1rmaco experimental acaban de sorprender a la comunidad m\u00e9dica. Un…<\/p>\n","protected":false},"author":1,"featured_media":59452,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[81],"tags":[],"class_list":["post-59445","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud"],"magazineBlocksPostFeaturedMedia":{"thumbnail":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-8-150x150.jpg","medium":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-8-300x164.jpg","medium_large":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-8-768x419.jpg","large":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-8-1024x559.jpg","1536x1536":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-8.jpg","2048x2048":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-8.jpg","newsmatic-featured":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-8-820x545.jpg","newsmatic-list":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-8-600x400.jpg","newsmatic-thumb":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-8-300x200.jpg","newsmatic-small":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-8-150x95.jpg","newsmatic-grid":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-8-400x250.jpg"},"magazineBlocksPostAuthor":{"name":"admin","avatar":"https:\/\/secure.gravatar.com\/avatar\/76e419471a2083bc3ceab22a763dbbf9b0c1bd15a6214cf3280e2c2dde4580f9?s=96&d=mm&r=g"},"magazineBlocksPostCommentsNumber":"0","magazineBlocksPostExcerpt":"M\u00e1s de 1.000 millones de personas en el mundo viven con obesidad y la cifra no para de crecer: la prevalencia entre adultos se duplic\u00f3 entre 1990 y 2022, seg\u00fan la Organizaci\u00f3n Mundial de la Salud (OMS). En ese contexto, los resultados de un nuevo f\u00e1rmaco experimental acaban de sorprender a la comunidad m\u00e9dica. Un...","magazineBlocksPostCategories":["Salud"],"magazineBlocksPostViewCount":4,"magazineBlocksPostReadTime":4,"magazine_blocks_featured_image_url":{"full":["https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-8.jpg",1408,768,false],"medium":["https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-8-300x164.jpg",300,164,true],"thumbnail":["https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas-8-150x150.jpg",150,150,true]},"magazine_blocks_author":{"display_name":"admin","author_link":"https:\/\/lobosnews.com.ar\/index.php\/author\/lobos-news\/"},"magazine_blocks_comment":0,"magazine_blocks_author_image":"https:\/\/secure.gravatar.com\/avatar\/76e419471a2083bc3ceab22a763dbbf9b0c1bd15a6214cf3280e2c2dde4580f9?s=96&d=mm&r=g","magazine_blocks_category":"Salud<\/a>","yoast_head":"\nQu\u00e9 se sabe sobre la retatrutida, el f\u00e1rmaco experimental que logr\u00f3 bajar el 28% del peso corporal en 80 semanas - Lobos News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lobosnews.com.ar\/index.php\/2026\/05\/25\/que-se-sabe-sobre-la-retatrutida-el-farmaco-experimental-que-logro-bajar-el-28-del-peso-corporal-en-80-semanas\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Qu\u00e9 se sabe sobre la retatrutida, el f\u00e1rmaco experimental que logr\u00f3 bajar el 28% del peso corporal en 80 semanas - Lobos News\" \/>\n<meta property=\"og:description\" content=\"M\u00e1s de 1.000 millones de personas en el mundo viven con obesidad y la cifra no para de crecer: la prevalencia entre adultos se duplic\u00f3 entre 1990 y 2022, seg\u00fan la Organizaci\u00f3n Mundial de la Salud (OMS). 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