Science Advances<\/b><\/i><\/span>, fue liderada por Neus Mart\u00ednez-Bosch<\/b> y Jos\u00e9 Y\u00e9lamos<\/b>, del Instituto de Investigaci\u00f3n del Hospital del Mar<\/b>, en Barcelona<\/b>. <\/p>\n![\"Investigadores](\"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/cancer-de-pancreas-descubren-una-proteina-que-protege-al-tumor-y-frena-las-defensas-del-cuerpo-1.jpg\")
<\/p>\n
Tambi\u00e9n colabor\u00f3 el cient\u00edfico argentino Gabriel Rabinovich<\/b>, investigador del Instituto de Biolog\u00eda y Medicina Experimental (IBYME) del Conicet,<\/b> la Facultad de Ciencias Exactas y Naturales de la Universidad de Buenos Aires<\/b> y del Instituto CaixaResearch de Barcelona<\/b>. <\/p>\n
Participaron cient\u00edficos del Instituto de Investigaciones Biom\u00e9dicas de Barcelona, la Universidad Pompeu Fabra y otras instituciones de Espa\u00f1a.<\/p>\n
La prote\u00edna que el tumor necesitaba para sobrevivir<\/h2>\n
El c\u00e1ncer de p\u00e1ncreas ocupa el tercer lugar entre las causas de muerte por c\u00e1ncer en el mundo. Su entorno celular es tan hostil para las defensas del cuerpo que lo hace resistente a casi todos los tratamientos disponibles.<\/p>\n
Los f\u00e1rmacos conocidos como inhibidores de PARP<\/b>, que son prote\u00ednas que reparan el ADN da\u00f1ado, representaron un avance en ciertos tumores<\/b>. Pero en el caso del c\u00e1ncer de p\u00e1ncreas solo funcionan en un grupo de pacientes: los que tienen mutaciones en los genes BRCA1 o BRCA2.<\/p>\n
Adem\u00e1s, los inhibidores de PARP disponibles no distinguen entre dos prote\u00ednas similares: PARP1 y PARP2. <\/p>\n
![\"Los](\"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/cancer-de-pancreas-descubren-una-proteina-que-protege-al-tumor-y-frena-las-defensas-del-cuerpo-2.jpg\")
<\/p>\n
Estudios previos ya hab\u00edan demostrado que eliminar PARP1 en ratones con c\u00e1ncer de p\u00e1ncreas no cambiaba ni la progresi\u00f3n del tumor ni la supervivencia de los animales. En ese contexto, los investigadores quisieron comprender cu\u00e1l era el papel de PARP2 en c\u00e1ncer de p\u00e1ncreas en particular.<\/p>\n
C\u00f3mo trabajaron los cient\u00edficos<\/h2>\n
Para entender qu\u00e9 hace PARP2 en el c\u00e1ncer de p\u00e1ncreas, los investigadores recurrieron a ratones con ese tumor. <\/p>\n
Usaron dos tipos: unos con el oncog\u00e9n Myc activado y otros con el oncog\u00e9n KrasG12D, la mutaci\u00f3n m\u00e1s frecuente en el c\u00e1ncer de p\u00e1ncreas humano. Un oncog\u00e9n es un gen que, al descontrolarse, empuja a las c\u00e9lulas sanas a convertirse en cancerosas.<\/p>\n
En ambos grupos, los investigadores eliminaron gen\u00e9ticamente la prote\u00edna PARP2 y observaron qu\u00e9 pasaba. El resultado fue contundente: los ratones sin PARP2 vivieron un 43% m\u00e1s, y el 75% super\u00f3 los seis meses de vida, frente al 14% del grupo sin modificaciones.<\/p>\n
![\"Un](\"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/cancer-de-pancreas-descubren-una-proteina-que-protege-al-tumor-y-frena-las-defensas-del-cuerpo-3.jpg\")
<\/p>\n
Sin PARP2, las c\u00e9lulas tumorales acumularon errores en su ADN y presentaron cromosomas en mal estado. Los cromosomas son las estructuras que guardan el ADN dentro de la c\u00e9lula; cuando se da\u00f1an, la c\u00e9lula cancerosa se vuelve mucho m\u00e1s vulnerable.<\/p>\n
Ese desorden gen\u00e9tico encendi\u00f3 una alarma interna llamada STING<\/b>. Esta v\u00eda produce se\u00f1ales qu\u00edmicas que le avisan al sistema inmune que hay c\u00e9lulas da\u00f1adas y que tiene que atacarlas.<\/p>\n
La respuesta del cuerpo fue inmediata: aumentaron los linfocitos T citot\u00f3xicos y las c\u00e9lulas NK, los \u201csoldados\u201d del sistema inmune que destruyen c\u00e9lulas tumorales. <\/p>\n
Al mismo tiempo, baj\u00f3 la presencia de las c\u00e9lulas que normalmente protegen al tumor, como los macr\u00f3fagos M2 y las c\u00e9lulas T reguladoras.<\/p>\n
![\"El](\"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/05\/cancer-de-pancreas-descubren-una-proteina-que-protege-al-tumor-y-frena-las-defensas-del-cuerpo-4.jpg\")
<\/p>\n
Los investigadores concluyeron que inhibir PARP2 de forma selectiva podr\u00eda ser una estrategia terap\u00e9utica real, porque debilita al tumor desde adentro y activa las defensas del cuerpo al mismo tiempo. <\/b><\/p>\n
Eso lo hace potencialmente valioso para pacientes que no responden a la inmunoterapia, un tratamiento que busca que el propio cuerpo frene al tumor.<\/p>\n
Los investigadores aclararon que el desarrollo de inhibidores espec\u00edficos de PARP2 todav\u00eda est\u00e1 en una etapa muy temprana y que ning\u00fan f\u00e1rmaco de este tipo se eval\u00faa en personas por el momento. <\/p>\n
Los resultados provienen de modelos animales, por lo que se necesitan m\u00e1s investigaciones antes de hablar de un tratamiento real para pacientes.<\/p>\n","protected":false},"excerpt":{"rendered":"
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