{"id":38942,"date":"2026-03-26T16:01:22","date_gmt":"2026-03-26T16:01:22","guid":{"rendered":"https:\/\/lobosnews.com.ar\/index.php\/2026\/03\/26\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-2\/"},"modified":"2026-03-26T16:42:01","modified_gmt":"2026-03-26T16:42:01","slug":"que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-2","status":"publish","type":"post","link":"https:\/\/lobosnews.com.ar\/index.php\/2026\/03\/26\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-2\/","title":{"rendered":"Qu\u00e9 es la enfermedad de Huntington y en qu\u00e9 consiste el \u201cpuente secreto\u201d que permite su avance en el cerebro"},"content":{"rendered":"

La enfermedad de Huntington<\/b><\/span> es un trastorno raro y hereditario que provoca movimientos involuntarios<\/b> y problemas de memoria. Afecta el cerebro poco a poco y suele aparecer en adultos j\u00f3venes o de mediana edad.<\/b><\/p>\n

Cient\u00edficos de los Estados Unidos y M\u00e9xico<\/b> consiguieron identificar que la prote\u00edna <\/b><\/span>t\u00f3xica de Huntington no queda atrapada en una sola neurona<\/b>, sino que se desplaza entre c\u00e9lulas.<\/p>\n

Lo hacen al usar nanotubos de membrana, que son canales microsc\u00f3picos que permiten que la enfermedad avance silenciosamente en el cerebro.<\/p>\n

\"El<\/p>\n

A traves de un estudio publicado en Science Advances<\/b><\/span>, investigadores de la Universidad Atl\u00e1ntica de Florida<\/b>, de los Estados Unidos, y la Universidad Nacional Aut\u00f3noma de M\u00e9xico<\/b>, entre otras instituciones, demostraron que las prote\u00ednas Rhes y SLC4A7 son esenciales para que se formen esos nanotubos y la huntingtina mutada pueda moverse de una neurona a otra. <\/p>\n

Al bloquear SLC4A7, los nanotubos desaparecen y la prote\u00edna da\u00f1ina deja de propagarse. El resultado se\u00f1ala un nuevo camino para desarrollar tratamientos que detengan la enfermedad de Huntington, al impedir que la prote\u00edna se extienda por el cerebro y cause m\u00e1s da\u00f1o.<\/p>\n

La traves\u00eda secreta de la prote\u00edna de Huntington<\/h2>\n

\"Investigadores<\/p>\n

La enfermedad de Huntington (EH) <\/b>se produce por una mutaci\u00f3n en el gen de la huntingtina, ubicado en el cromosoma 4. <\/p>\n

Esta alteraci\u00f3n genera una producci\u00f3n anormal de la prote\u00edna, que da\u00f1a progresivamente ciertas \u00e1reas del cerebro responsables del control motor, las emociones y las capacidades cognitivas, explic\u00f3 a Infobae <\/b><\/span>la doctora Mar\u00eda Eugenia Gonz\u00e1lez Toledo<\/b>, coordinadora m\u00e9dica General de INECO.<\/p>\n

Uno de los grandes desaf\u00edos cient\u00edficos era comprender c\u00f3mo la huntingtina mutada pasaba de una neurona a otra y expand\u00eda el da\u00f1o cerebral. Durante mucho tiempo, los cient\u00edficos sospecharon que la prote\u00edna no se limitaba a una sola c\u00e9lula, pero no sab\u00edan c\u00f3mo lograba viajar y empeorar la enfermedad. Por eso, los investigadores que publicaron en <\/b>Science Advances<\/i> intentaron averiguar si la prote\u00edna t\u00f3xica usaba caminos f\u00edsicos y directos entre c\u00e9lulas, adem\u00e1s de las conocidas se\u00f1ales qu\u00edmicas. <\/b><\/p>\n

Entender ese proceso resultaba clave para imaginar nuevas terapias que pudieran bloquear la expansi\u00f3n del da\u00f1o desde el principio.<\/p>\n

Claves en nanotubos de membrana<\/h2>\n

\"Las<\/p>\n

En el laboratorio, los investigadores detectaron que dos prote\u00ednas, Rhes y SLC4A7, colaboran en la superficie de las neuronas. Rhes act\u00faa como activador y SLC4A7 regula el equilibrio interno de la c\u00e9lula. Juntas, permiten que se formen los nanotubos de membrana, canales tan peque\u00f1os que solo pueden verse con microscopios especiales.<\/p>\n

A trav\u00e9s de esos nanotubos, la prote\u00edna da\u00f1ina viaja r\u00e1pidamente entre neuronas, extendiendo la enfermedad. <\/p>\n

Srinivasa Subramaniam, uno de los investigadores, dijo: \u201cEste trabajo cambia <\/b>fundamentalmente la manera en que pensamos sobre la progresi\u00f3n de la enfermedad de Huntington\u201d.<\/b><\/p>\n

\"La<\/p>\n

El equipo bloque\u00f3 SLC4A7 mediante herramientas gen\u00e9ticas y medicamentos. Cuando esta prote\u00edna no funcionaba, los nanotubos de membrana no se formaban y la huntingtina mutada quedaba atrapada en la c\u00e9lula original. <\/p>\n

Lo mismo ocurri\u00f3 en c\u00e9lulas en laboratorio y en cerebros de ratones modificados para el estudio.<\/p>\n

En los ratones sin SLC4A7, la transferencia de la prote\u00edna t\u00f3xica en el cerebro se redujo, especialmente en el estriado, la regi\u00f3n m\u00e1s afectada por la enfermedad. <\/p>\n

\"El<\/p>\n

Estos resultados apoyaron la idea de que cortar estos puentes puede frenar el avance de la patolog\u00eda.<\/p>\n

La investigaci\u00f3n sugiri\u00f3 que la colaboraci\u00f3n entre Rhes y SLC4A7 resulta esencial para que la prote\u00edna da\u00f1ina se propague. <\/p>\n

Subramaniam mencion\u00f3 que \u201cal identificar SLC4A7 como socio clave de Rhes, hemos descubierto un nuevo objetivo potencial para detener esa propagaci\u00f3n en su origen\u201d.<\/p>\n

Un hallazgo con impacto m\u00e1s all\u00e1 de Huntington<\/h2>\n

\"El<\/p>\n

El descubrimiento de los nanotubos de membrana tiene implicancias en otras enfermedades, ya que tambi\u00e9n aparecen en trastornos neurodegenerativos y en c\u00e1ncer.<\/p>\n

En esas afecciones, tambi\u00e9n las c\u00e9lulas usan rutas similares para pasar se\u00f1ales y defenderse de medicamentos. As\u00ed, el mecanismo podr\u00eda repetirse en distintos tipos de da\u00f1o cerebral.<\/p>\n

Los cient\u00edficos sostuvieron que desarrollar medicamentos para bloquear SLC4A7 puede ser clave para impedir la formaci\u00f3n de nanotubos<\/b> y la transmisi\u00f3n de la prote\u00edna mutada. <\/p>\n

\"Los<\/p>\n

Aclararon que, aunque los resultados en c\u00e9lulas y ratones son prometedores, falta probar la seguridad y eficacia en seres humanos.<\/p>\n

Sin embargo, los resultados del estudio despiertan m\u00e1s esperanza para favorecer el desarrollo de mejores terapias que no solo de la enfermedad de Huntington, sino tambi\u00e9n de otras afecciones cerebrales y algunos tipos de c\u00e1ncer.<\/p>\n","protected":false},"excerpt":{"rendered":"

La enfermedad de Huntington es un trastorno raro y hereditario que provoca movimientos involuntarios y problemas de memoria. Afecta el cerebro poco a poco y suele aparecer en adultos j\u00f3venes o de mediana edad. Cient\u00edficos de los Estados Unidos y M\u00e9xico consiguieron identificar que la prote\u00edna t\u00f3xica de Huntington no queda atrapada en una sola…<\/p>\n","protected":false},"author":1,"featured_media":38956,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[81],"tags":[],"class_list":["post-38942","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud"],"magazineBlocksPostFeaturedMedia":{"thumbnail":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/03\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-25-150x150.jpg","medium":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/03\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-25-300x164.jpg","medium_large":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/03\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-25-768x419.jpg","large":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/03\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-25-1024x559.jpg","1536x1536":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/03\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-25.jpg","2048x2048":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/03\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-25.jpg","newsmatic-featured":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/03\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-25-820x545.jpg","newsmatic-list":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/03\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-25-600x400.jpg","newsmatic-thumb":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/03\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-25-300x200.jpg","newsmatic-small":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/03\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-25-150x95.jpg","newsmatic-grid":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/03\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-25-400x250.jpg"},"magazineBlocksPostAuthor":{"name":"admin","avatar":"https:\/\/secure.gravatar.com\/avatar\/76e419471a2083bc3ceab22a763dbbf9b0c1bd15a6214cf3280e2c2dde4580f9?s=96&d=mm&r=g"},"magazineBlocksPostCommentsNumber":"0","magazineBlocksPostExcerpt":"La enfermedad de Huntington es un trastorno raro y hereditario que provoca movimientos involuntarios y problemas de memoria. Afecta el cerebro poco a poco y suele aparecer en adultos j\u00f3venes o de mediana edad. Cient\u00edficos de los Estados Unidos y M\u00e9xico consiguieron identificar que la prote\u00edna t\u00f3xica de Huntington no queda atrapada en una sola...","magazineBlocksPostCategories":["Salud"],"magazineBlocksPostViewCount":96,"magazineBlocksPostReadTime":5,"magazine_blocks_featured_image_url":{"full":["https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/03\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-25.jpg",1408,768,false],"medium":["https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/03\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-25-300x164.jpg",300,164,true],"thumbnail":["https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/03\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-25-150x150.jpg",150,150,true]},"magazine_blocks_author":{"display_name":"admin","author_link":"https:\/\/lobosnews.com.ar\/index.php\/author\/lobos-news\/"},"magazine_blocks_comment":0,"magazine_blocks_author_image":"https:\/\/secure.gravatar.com\/avatar\/76e419471a2083bc3ceab22a763dbbf9b0c1bd15a6214cf3280e2c2dde4580f9?s=96&d=mm&r=g","magazine_blocks_category":"Salud<\/a>","yoast_head":"\nQu\u00e9 es la enfermedad de Huntington y en qu\u00e9 consiste el \u201cpuente secreto\u201d que permite su avance en el cerebro - Lobos News<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/lobosnews.com.ar\/index.php\/2026\/03\/26\/que-es-la-enfermedad-de-huntington-y-en-que-consiste-el-puente-secreto-que-permite-su-avance-en-el-cerebro-2\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Qu\u00e9 es la enfermedad de Huntington y en qu\u00e9 consiste el \u201cpuente secreto\u201d que permite su avance en el cerebro - Lobos News\" \/>\n<meta property=\"og:description\" content=\"La enfermedad de Huntington es un trastorno raro y hereditario que provoca movimientos involuntarios y problemas de memoria. 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