Cell Reports Medicine<\/b><\/i><\/span>.<\/p>\nImpacto y riesgos de la gripe aviar<\/h2>\n
![\"La](\"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/01\/una-vacuna-nasal-experimental-brindo-proteccion-contra-la-gripe-aviar-en-animales-2.jpg\")
<\/p>\n
La gripe aviar H5N1<\/b> afecta sobre todo a las aves, produce brotes con alta mortalidad y genera grandes p\u00e9rdidas en la industria av\u00edcola.<\/p>\n
El virus cruz\u00f3 la barrera de especies y ya infect\u00f3 a mam\u00edferos como focas, zorros y vacas, lo que prueba su capacidad de adaptarse y saltar entre distintos animales.<\/p>\n
Estos episodios aumentan la preocupaci\u00f3n por posibles mutaciones y por el riesgo de una propagaci\u00f3n m\u00e1s amplia.<\/p>\n
En humanos, la infecci\u00f3n por H5N1<\/b> aparece en personas expuestas a aves enfermas, con cuadros cl\u00ednicos graves y una tasa de mortalidad elevada.<\/p>\n
![\"Ya](\"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/01\/una-vacuna-nasal-experimental-brindo-proteccion-contra-la-gripe-aviar-en-animales-3.jpg\")
<\/p>\n
La Organizaci\u00f3n Mundial de la Salud (OMS)<\/b> considera bajo el riesgo de pandemia en el presente, pero advierte que el virus cambia y puede adquirir la capacidad de transmitirse con facilidad entre personas.<\/p>\n
La vigilancia constante resulta fundamental para anticipar y contener cualquier amenaza.<\/p>\n
Un respiro frente a la amenaza aviar<\/h2>\n
![\"El](\"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/01\/una-vacuna-nasal-experimental-brindo-proteccion-contra-la-gripe-aviar-en-animales-4.jpg\")
<\/p>\n
El objetivo de los cient\u00edficos de la Facultad de Medicina de la Universidad de Washington fue crear una vacuna nasal para proteger contra la gripe aviar H5N1<\/b>.<\/p>\n
Esta variante se detect\u00f3 en Estados Unidos en 2014 y desde entonces salt\u00f3 de aves silvestres a animales de granja y a personas.<\/p>\n
Desde 2022 se reportaron m\u00e1s de 70 casos humanos y dos muertes, lo que mantiene el riesgo de una posible pandemia.<\/p>\n
El equipo busc\u00f3 una soluci\u00f3n que actuara directamente en las v\u00edas respiratorias, el punto de entrada del virus.<\/p>\n
![\"La](\"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/01\/una-vacuna-nasal-experimental-brindo-proteccion-contra-la-gripe-aviar-en-animales-5.jpg\")
<\/p>\n
Seleccionaron prote\u00ednas del H5N1<\/b> presentes en variantes humanas y crearon un ant\u00edgeno \u00f3ptimo.<\/p>\n
Ese ant\u00edgeno se insert\u00f3 en un adenovirus inofensivo, incapaz de replicarse, para funcionar como veh\u00edculo de la vacuna.<\/p>\n
El doctor Jacco Boon<\/b> explic\u00f3: \u201cNuestra vacuna a la nariz y las v\u00edas respiratorias superiores puede proteger contra la infecci\u00f3n respiratoria superior y tambi\u00e9n contra la enfermedad grave\u201d. <\/p>\n
Esto podr\u00eda ofrecer mejor defensa contra la transmisi\u00f3n porque act\u00faa sobre la infecci\u00f3n desde el inicio.<\/p>\n
El estudio se realiz\u00f3 en h\u00e1msteres y ratones, donde la vacuna nasal gener\u00f3 una respuesta inmune fuerte. Los animales vacunados no se infectaron, incluso con dosis bajas y exposiciones altas al virus.<\/p>\n
Los investigadores compararon la vacuna nasal con las vacunas tradicionales contra la gripe estacional. Observaron que esas aplicaciones ofrecieron poca protecci\u00f3n frente al H5N1<\/b> en los modelos animales utilizados.<\/p>\n
La formulaci\u00f3n nasal de gripe aviar tambi\u00e9n super\u00f3 en eficacia a la misma vacuna aplicada por inyecci\u00f3n.<\/p>\n
![\"Expertos](\"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/01\/una-vacuna-nasal-experimental-brindo-proteccion-contra-la-gripe-aviar-en-animales-6.jpg\")
<\/p>\n
El doctor Michael Diamond<\/b> se\u00f1al\u00f3: \u201cHemos demostrado que esta plataforma de administraci\u00f3n nasal que ideamos, dise\u00f1amos y pusimos a prueba en la Facultad de Medicina de la Universidad de Washington puede impedir que la infecci\u00f3n por H5N1<\/b> se instale en nariz y pulmones\u201d.<\/p>\n
Los investigadores comprobaron que la vacuna nasal mantiene su eficacia en animales con defensas previas por otras gripes o vacunas.<\/p>\n
Los resultados abren la puerta a que se realicen m\u00e1s pruebas en animales y en tejidos humanos. El equipo planea desarrollar variantes que refuercen la respuesta inmunitaria y mejoren la protecci\u00f3n.<\/p>\n","protected":false},"excerpt":{"rendered":"
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Millones de aves fueron sacrificadas y algunos pa\u00edses iniciaron campa\u00f1as de vacunaci\u00f3n para controlar la…<\/p>\n","protected":false},"author":1,"featured_media":13715,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[81],"tags":[],"class_list":["post-13706","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-salud"],"magazineBlocksPostFeaturedMedia":{"thumbnail":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/01\/una-vacuna-nasal-experimental-brindo-proteccion-contra-la-gripe-aviar-en-animales-12-150x150.jpg","medium":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/01\/una-vacuna-nasal-experimental-brindo-proteccion-contra-la-gripe-aviar-en-animales-12-300x200.jpg","medium_large":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/01\/una-vacuna-nasal-experimental-brindo-proteccion-contra-la-gripe-aviar-en-animales-12-768x512.jpg","large":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/01\/una-vacuna-nasal-experimental-brindo-proteccion-contra-la-gripe-aviar-en-animales-12-1024x683.jpg","1536x1536":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/01\/una-vacuna-nasal-experimental-brindo-proteccion-contra-la-gripe-aviar-en-animales-12-1536x1024.jpg","2048x2048":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/01\/una-vacuna-nasal-experimental-brindo-proteccion-contra-la-gripe-aviar-en-animales-12-2048x1365.jpg","newsmatic-featured":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/01\/una-vacuna-nasal-experimental-brindo-proteccion-contra-la-gripe-aviar-en-animales-12-820x545.jpg","newsmatic-list":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/01\/una-vacuna-nasal-experimental-brindo-proteccion-contra-la-gripe-aviar-en-animales-12-600x400.jpg","newsmatic-thumb":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/01\/una-vacuna-nasal-experimental-brindo-proteccion-contra-la-gripe-aviar-en-animales-12-300x200.jpg","newsmatic-small":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/01\/una-vacuna-nasal-experimental-brindo-proteccion-contra-la-gripe-aviar-en-animales-12-150x95.jpg","newsmatic-grid":"https:\/\/lobosnews.com.ar\/wp-content\/uploads\/2026\/01\/una-vacuna-nasal-experimental-brindo-proteccion-contra-la-gripe-aviar-en-animales-12-400x250.jpg"},"magazineBlocksPostAuthor":{"name":"admin","avatar":"https:\/\/secure.gravatar.com\/avatar\/76e419471a2083bc3ceab22a763dbbf9b0c1bd15a6214cf3280e2c2dde4580f9?s=96&d=mm&r=g"},"magazineBlocksPostCommentsNumber":"0","magazineBlocksPostExcerpt":"Desde 2020, la gripe aviar H5N1 caus\u00f3 brotes masivos en aves y salt\u00f3 a mam\u00edferos, como focas y vacas, en varias regiones del mundo, incluyendo Am\u00e9rica Latina. 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